Nigel Irwin Selected Research

(pGlu-Gln)-CCK-8

8/2015	A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice.
1/2013	Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial effects in genetic ob/ob mice.
1/2013	Metabolic effects of activation of CCK receptor signaling pathways by twice-daily administration of the enzyme-resistant CCK-8 analog, (pGlu-Gln)-CCK-8, in normal mice.

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Nigel Irwin Research Topics

Disease

57	Body Weight (Weight, Body) 01/2024 - 09/2004
51	Insulin Resistance 11/2023 - 09/2004
40	Obesity 01/2024 - 08/2005
39	Type 2 Diabetes Mellitus (MODY) 09/2023 - 12/2003
7	Glucose Intolerance 04/2024 - 02/2006
6	Weight Loss (Weight Reduction) 04/2023 - 01/2015
3	Bone Resorption 10/2016 - 10/2013
2	Hyperplasia 01/2023 - 08/2005
2	Metabolic Diseases (Metabolic Disease) 01/2022 - 01/2021
2	Cognitive Dysfunction 11/2015 - 09/2010
2	Hypertrophy 12/2007 - 08/2005
1	Diabetes Mellitus 01/2024
1	Bone Fractures (Bone Fracture) 01/2024
1	Feeding and Eating Disorders (Eating Disorder) 09/2023
1	Bulimia (Binge Eating) 09/2023
1	Anorexia 09/2023
1	Short Bowel Syndrome 01/2021
1	Body Weight Changes 01/2020
1	Weight Gain 01/2020
1	Hypoglycemia (Reactive Hypoglycemia) 04/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2015
1	Prediabetic State (Prediabetes) 11/2015
1	Inflammation (Inflammations) 11/2014

Drug/Important Bio-Agent (IBA)

60	Glucose (Dextrose)FDA LinkGeneric 04/2024 - 08/2005
42	Insulin (Novolin)FDA Link 01/2024 - 08/2005
30	Peptides (Polypeptides)IBA 09/2023 - 09/2005
20	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2024 - 08/2006
16	Glucagon (Glukagon)FDA Link 01/2024 - 12/2003
12	xenin 25 (xenin)IBA 01/2021 - 08/2012
11	gastric inhibitory polypeptide receptorIBA 04/2023 - 08/2005
9	Exenatide (Byetta)FDA Link 04/2024 - 02/2009
8	Hormones (Hormone)IBA 01/2024 - 12/2003
8	Blood Glucose (Blood Sugar)IBA 11/2022 - 01/2016
7	IncretinsIBA 01/2020 - 12/2003
7	Pro(3)- glucose-dependent insulinotropic polypeptideIBA 07/2012 - 09/2004
6	Streptozocin (Streptozotocin)FDA Link 01/2021 - 10/2011
6	Triglycerides (Triacylglycerol)IBA 10/2020 - 12/2007
5	EnzymesIBA 01/2023 - 02/2009
5	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 10/2013 - 09/2005
4	Liraglutide FDA Link 04/2023 - 03/2015
4	Cholecystokinin (Pancreozymin)IBA 01/2018 - 08/2013
4	OxyntomodulinIBA 01/2016 - 12/2013
3	Glucagon-Like Peptide-1 ReceptorIBA 04/2023 - 04/2007
3	Glucagon Receptors (Glucagon Receptor)IBA 01/2023 - 04/2014
3	Sitagliptin Phosphate (Januvia)FDA Link 01/2021 - 01/2019
3	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 01/2020 - 01/2009
3	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018 - 10/2006
3	(pGlu-Gln)-CCK-8IBA 08/2015 - 01/2013
3	monomethoxypolyethylene glycol (MPEG)IBA 08/2013 - 06/2008
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2024 - 01/2018
2	Peptide YYIBA 01/2021 - 01/2018
2	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 01/2021 - 01/2013
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2020 - 11/2016
2	Amylases FDA Link 09/2018 - 01/2018
2	Glucagon-Like Peptide-1 Receptor AgonistsIBA 12/2015 - 02/2010
2	PalmitatesIBA 08/2012 - 02/2005
2	Metformin (Glucophage)FDA LinkGeneric 12/2010 - 10/2006
2	AdiponectinIBA 02/2009 - 06/2008
2	CannabinoidsIBA 06/2008 - 02/2008
2	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 06/2008 - 02/2008
2	AM 251 (AM251)IBA 06/2008 - 02/2008
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 07/2007 - 04/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2006 - 09/2005
1	Dopamine (Intropin)FDA LinkGeneric 04/2024
1	Alanine (L-Alanine)FDA Link 04/2024
1	Levodopa (L Dopa)FDA LinkGeneric 04/2024
1	Glucagon-Like Peptide-2 ReceptorIBA 01/2024
1	Transcription Factors (Transcription Factor)IBA 01/2024
1	GalaninIBA 09/2023
1	semaglutideIBA 04/2023
1	tirzepatideIBA 04/2023
1	Pancreatic Polypeptide (Pancreatic Polypeptide (PP))IBA 01/2023
1	neuropeptide Y4 receptorIBA 01/2023
1	Therapeutic UsesIBA 01/2023
1	NeuropeptidesIBA 01/2023
1	Artemether FDA Link 11/2022
1	Vasopressins (Vasopressin)IBA 01/2022
1	ApelinIBA 01/2022
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2021
1	Pyruvic Acid (Pyruvate)IBA 01/2021
1	methionine aminopeptidase 2IBA 01/2021
1	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 01/2021
1	AmidesIBA 12/2020
1	peptide YY (1-36)IBA 01/2020
1	LipidsIBA 01/2020
1	AntibodiesIBA 01/2020
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2020
1	Ala(2)- glucose-dependent insulinotropic polypeptideIBA 01/2020
1	dapagliflozinIBA 01/2020
1	GastrinsIBA 09/2018
1	Glutamine (L-Glutamine)FDA Link 04/2016
1	Leptin ReceptorsIBA 01/2016
1	MineralsIBA 01/2016
1	Proteins (Proteins, Gene)FDA Link 11/2014
1	8-hydroxyguanineIBA 11/2014

Therapy/Procedure

15	Therapeutics 04/2023 - 02/2005
4	Injections 02/2009 - 09/2005
3	Intraperitoneal Injections 12/2007 - 02/2006
1	Drug Therapy (Chemotherapy) 04/2023
1	Bariatric Surgery 12/2021